Safe and non-invasive measurement of physiology
Quantiphyse enables radiologists and clinicians to look inside the body and measure physiology in real time. Our imaging technology is both safe and non-invasive, and will improve the understanding of disease and support clinical diagnosis.
Next-generation MRI analysis
Quantiphyse provides researchers with spatially-resolved measurements of human physiology using the MRI techniques ASL and CEST. These techniques are both safe and non-invasive, and will improve the understanding of disease and accelerate clinical trials.
Advantages For Clinicians & Radiologists
We provide quantitative physiological measures (perfusion, arterial transit time, local pH, protein content) within automatically generated RoIs (for example, cortical parcellations). These have many clinical applications .
Non-invasive imaging reduces scan session time and increases scanner throughput. Our quanitification tools can generate pre-populated reports with measures of interest, enhancing the radiological workflow.
Improved Monitoring & Management
Cost and safety advantages facilitate improved long term patient monitoring and management – longitudinal scans are safer, cheaper and faster than using PET or Gd Enhanced MRI.
Wider Patient Access
Non-invasive ASL and CEST can be safely used on patient groups that are otherwise contra-indicated, for example paediatrics and kindey-impaired patients.
Cross Vender Support
Our tools are scanner and sequence agnostic – all major vendors are supported.
No New Hardware
ASL and CEST sequences can be run on the majority of existing clinical MRI scanners – no new hardware required.
Advantages for Clinical Trials and Contract Research Organisations
Spatially Resolved Quantitative Measurements
Access to spatially resolved physiological measurements: for example, perfusion and arterial transit time in the brain, or local pH and protein content within a tumour.
Modular Quantification Algorithms
Quantiphyse provides access to a core suite of quantification tools. These can be integrated within an existing imaging platform.
Increased Safety & Lower Costs
ASL and CEST are safer for patients (being non-invasive) and are cheaper than a PET or Gd-MRI session. Their safety advantages are particularly favourable for longitudinal studies with repeat acquisitions.
Non-invasive imaging is faster to prepare and acquire than the equivalent PET or Gd-MRI. This enables faster stratification of patient cohorts and a quicker means of establishing baseline.
Wider Patient Access
ASL and CEST can be used to support trials on previously contra-indicated groups (paediatrics, pregnancy care, or kidney-impaired patients).
Visualisation & Analysis
Quantiphyse optionally provides an extensible visualisation and analysis platform on which the algorithms can sit, including the ability to prototype and run analysis pipelines across multiple subjects. We can also provide quality control measures for large datasets can be incorporated into pipelines.
- Diagnosis of Alzheimer’s disease or dementia
- Investigation of tumour; differentiating tumour progression from benign causes of enhancement
- Investigation of stroke, ischemia or other circulatory problem in the brain, both in the acute and chronic phase
- Investigation of kidney function
- Investigation of epilepsy
- Investigation of mild traumatic brain injury or PTSD
- Assessment of cerebral ischemia
- Assessment of solid tumour, particularly measuring response to treatment
- Assessment of osteoarthritis
- Assessment of muscle physiology
- Assessment of lymphedema
Quantiphyse is a suite of world-leading quantification tools for physiological MRI data. The modalities we support are:
Chemical Exchange Saturation Transfer MRI (CEST MRI) is a molecular MR technique that captures the chemical properties (such as pH or protein content) of proton pools at concentrations too low for conventional MRI. Our CEST quanitification tool can be run both model-based and model-free to yield proton concentration and exchange maps, proton transfer ration (CESTR*). Correction for field inhomogeneity and T1/T2 effects is inherent to our approach.
Arterial Spin Labelling (ASL) is an MRI method for imaging the delivery of blood to body tissues, and is most widely used in the brain. Quantiphyse can perform all the main steps of ASL analysis including Generation of perfusion-weighted image (label-control subtraction); Kinetic modelling and; Calculation of perfusion in absolute units (calibration).
Dynamic Contrast Enhanced MRI (DCE-MRI) is an physiological MRI technique that captures the tissue T1 changes over time after the administration of a gadolinium contrast agent, revealing aspects of perfusion and permeability. DCE MRI primarily has application in providing perfusion based biomarkers in tumours. Quanitphyse provides both Bayesian and Least-squares quanitification for DCE data, yielding parameters such as Ktrans, Fp, PS, Vp and Ve
Quantiphyse is the culmination of twenty years of research and development in physiological modelling at the Universities of Oxford and Nottingham, led by Professor Michael Chappell.
The ASL and CEST quantification tools included in Quantiphyse are the gold-standard for academic research. They have been used in some of the largest international studies of brain function, such as the UK Biobank and the Human Connectome Project in Aging.